Indications and Medication Precautions for Dimethyl Fumarate, Biogen Version, USA
DimethylFumarate is an oral immunomodulatory agent used to treat recurrent multiple sclerosis (RMS), controlling disease progression through anti-inflammatory and neuroprotective effects.
1. Indications
Dimethyl fumarate is suitable for the treatment of adult relapsing multiple sclerosis, including clinically isolated syndrome (CIS), relapsing remitting MS (RRMS), and active secondary progressive MS (SPMS). It can reduce the clinical recurrence rate and brain lesion activity.
2. Medication precautions
(1) Dose plan
The initial dose is 120mg twice daily, and after 7 days, it is increased to the maintenance dose of 240mg twice daily. It must be taken with meals to reduce gastrointestinal irritation, and the whole pill should not be crushed or chewed.
(2) Adverse reaction monitoring
In the early stages of treatment, common symptoms include flushing (40%) and gastrointestinal reactions (35-40%), which usually subside within 2-4 weeks. Regular monitoring of lymphocyte count is required, and medication should be suspended for severe lymphocyte reduction (<0.5 × 10 ⁹/L).
(3) Special populations
Pregnant women need to assess the benefits and risks of using it; Prohibited during lactation period; Elderly patients do not need to adjust the dosage but need to strengthen monitoring; Use with caution in patients with severe liver and kidney dysfunction. Women of childbearing age should take contraceptive measures during treatment.
(4) Drug interactions
When used in combination with immunosuppressants, it may increase the risk of infection. Live vaccination should be avoided during the treatment period. CYP inducers may reduce the efficacy of this product.
(5) Excessive processing
Single overdose usually manifests as worsening symptoms and requires symptomatic supportive treatment. If activated carbon adsorption is considered within 2 hours after taking medication, there is no specific antidote.
3. Storage temperature
It should be stored at 20 ° C to 25 ° C (68 ° F to 77 ° F), and short-term exposure to 15 ° C to 30 ° C (59 ° F to 86 ° F) is allowed. Avoid high temperatures and freezing.
4. Packaging requirements
Keep the original packaging sealed to prevent moisture and oxidation. Capsules should be stored in their original bottles and taken immediately after removal.
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