The mechanism of action, drug interactions, and dietary precautions of Mydrephrine P Ophthalmic Solution from Japan
Compound Topiramine Ophthalmic Solution achieves mydriatic effect through anticholinergic action, but attention should be paid to its interaction with other drugs and dietary effects. Reasonable use can reduce adverse reactions and ensure the effectiveness of the examination.
1. Mechanism of action
The main components of compound topiramine eye drops are topiramine and epinephrine. Topiramine blocks the M receptor of the iris sphincter, allowing the pupil dilater muscle to dominate and produce mydriatic effects. Deoxyepinephrine stimulates alpha receptors to constrict conjunctival blood vessels, reducing congestion.
2 drug interactions
(1) Co administration with anticholinergic drugs such as atropine may enhance the mydriatic effect and increase the risk of elevated intraocular pressure.
(2) The combination with monoamine oxidase inhibitors may enhance the pressor effect of norepinephrine, and caution should be exercised.
(3) Tricyclic antidepressants may enhance the anticholinergic effect of topiramine and should be avoided for simultaneous use.
3 Dietary precautions
(1) Avoid drinking alcohol during medication as it may worsen eye congestion or overall discomfort.
(2) Caffeine intake may enhance the excitatory effect of norepinephrine, and it is recommended to limit consumption.
(3) A high-fat diet may delay drug absorption, so it is advisable to maintain a light diet 2 hours before the examination.
4 Common Adverse Reactions
Compound topiramine eye drops may cause local discomfort such as eye irritation, burning sensation, and tearing. Some patients may experience symptoms such as blurred vision and photophobia. These reactions are usually short-lived and gradually decrease with drug metabolism.
5 usage suggestions
(1) Avoid driving or operating machinery after medication until vision is fully restored.
(2) Wearing sunglasses during mydriasis can alleviate photophobia symptoms and improve comfort.
(3) Avoid strong light stimulation and protect dilated pupils within 6-8 hours after examination.
Disclaimer：《The mechanism of action, drug interactions, and dietary precautions of Mydrephrine P Ophthalmic Solution from Japan》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！