Prohibited populations, foods, and restrictions of Faropenem from Maruho Corporation in Japan
As a beta lactam antibiotic, the use of Faropenem must strictly follow contraindications, dietary restrictions, and special conditions. The following provides a detailed explanation from three aspects: classification of taboo populations, list of taboo foods, and medication restrictions to ensure the safety and effectiveness of clinical medication.
1. Taboo population
(1) Allergic patients: Those who have a history of allergies to Faropenem or other beta lactam antibiotics (such as penicillin and cephalosporins) should not use it, as it may cause serious allergic reactions.
(2) Specific disease patients: severe renal insufficiency (creatinine clearance rate<30mL/min) requiring dose adjustment; Patients with central nervous system diseases such as epilepsy should use caution as it may lower the threshold for epileptic seizures.
(3) Special physiological state: Insufficient safety data during pregnancy, limited to use only when necessary; Breastfeeding should be suspended during lactation as medication may be secreted into breast milk.
2. Forbidden foods
(1) Alcoholic beverages: Do not drink alcohol during medication and within 72 hours after discontinuation, as it may cause disulfiram like reactions (facial flushing, palpitations, etc.).
(2) High fat diet: Taking after meals can reduce drug absorption by 30%. It is recommended to take on an empty stomach or 1 hour before meals to ensure efficacy.
(3) Calcium/magnesium containing preparations: including milk, antacids, etc., may form chelates that affect absorption, and should be taken at least 2 hours apart.
3. Restrictive conditions
(1) Course control: The conventional treatment cycle should not exceed 14 days, and long-term use may lead to secondary infections or increased bacterial resistance.
(2) Monitoring requirements: Regular check of liver and kidney function is required during medication; If diarrhea lasts for more than 48 hours, one should be alert to pseudomembranous colitis and stop taking medication immediately.
(3) Special dosage form restrictions: Chewable tablets must be thoroughly chewed before swallowing, and sustained-release tablets cannot be broken or crushed, otherwise it will damage the drug release system.
Disclaimer：《Prohibited populations, foods, and restrictions of Faropenem from Maruho Corporation in Japan》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！