The efficacy and drug interactions of Andriol Testoapps capsules from the United States
As an oral testosterone substitute, the pharmacological properties and unique drug interaction mechanisms of Andriol Testoapps capsules require special attention. This drug exerts its androgenic effects through absorption by the lymphatic system, and there are multiple contraindications to concurrent use that require caution.
1. Pharmacological mechanism of action
(1) Androgen replacement effect
By hydrolyzing testosterone undecylate into testosterone, it supplements the deficiency of endogenous androgens. Clinical manifestations include improving symptoms of hypogonadism, including sexual desire recovery and increased muscle mass.
(2) Metabolic activation effect
Enhance protein assimilation and promote red blood cell production. May cause an increase in hemoglobin levels, and regular monitoring of hemorheological indicators is necessary.
2. Drug interactions
(1) Anticoagulant drugs
Possible enhancement of warfarin effect requires frequent monitoring of INR values. The interaction with new oral anticoagulants such as rivaroxaban is not yet clear.
(2) Hypoglycemic drugs
It may reduce insulin sensitivity, and diabetes patients need to adjust the hypoglycemic program. Be cautious of the risk of ketoacidosis when using SGLT2 inhibitors in combination.
(3) CYP3A4 influencing agent
Strong CYP3A4 inhibitors, such as ketoconazole, may increase blood drug concentrations. Inducing agents (such as rifampicin) may reduce efficacy and require dosage adjustment.
3. Special precautions
(1) Absorbing influencing factors
It should be taken with a high-fat meal, but the fat intake should be controlled between 10-40g. Excessive fat may cause absorption fluctuations and lead to adverse reactions.
(2) Monitoring requirements
Prostate specific antigen (PSA) needs to be evaluated before treatment. Monitor hematocrit, liver function, and blood lipid levels every 3 months during medication.
4. Duration of action
(1) Effective time
Blood drug peak is reached 12-24 hours after a single administration. Clinical symptom improvement can only be observed after 2-4 weeks of continuous treatment.
(2) Metabolic elimination
Mainly metabolized by the liver, with a half-life of approximately 1.5 hours. But the sustained-release properties of the undecyl ester form can maintain 24-hour efficacy.
Disclaimer：《The efficacy and drug interactions of Andriol Testoapps capsules from the United States》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！