Medical Information

Rivaroxaban is an oral anticoagulant primarily used for the prevention and treatment of thromboembolic diseases. Its common side effects include increased risk of bleeding, gastrointestinal discomfort, etc. Targeted preventive measures need to be taken to ensure the safety and effectiveness of medication.

1. Common side effects and treatment

(1) Risk of bleeding

Gingival bleeding, nosebleeds, or mild subcutaneous bruising are more common. It is recommended to use a soft bristled toothbrush to avoid vigorous exercise and external injuries. If there is continuous bleeding, seek medical attention.

(2) Gastrointestinal reactions

Nausea and indigestion often occur in the early stages of medication. It is recommended to take with meals and drink water in portions to alleviate symptoms. Severe diarrhea requires vigilance against dehydration.

2. Dealing with serious side effects

(1) Massive bleeding

Hematemesis, black stool or hematuria indicate internal bleeding, and medication should be stopped immediately for medical treatment. Prepare the reversal agent Andexanetalfa for emergency use.

(2) Allergic reactions

Rash accompanied by difficulty breathing is considered an emergency. After the first medication, it is necessary to observe for 30 minutes. It is contraindicated for individuals with previous allergies.

3. Protection for special populations

(1) Renal insufficiency

Creatinine clearance rate<30ml/min needs to be reduced. Monitor kidney function monthly and avoid using NSAIDs in combination.

(2) Elderly patients

For those at high risk of falling, it is recommended to use anti slip pads. Regularly check hemoglobin and be alert to occult bleeding.

4. Drug interactions

(1) Antiplatelet drugs

The risk of bleeding doubles when combined with aspirin. Medication should be stopped for 5 days before scheduled surgery.

(2) CYP3A4 inhibitor

Ketoconazole can increase blood drug concentration by three times. If necessary, alternative anticoagulation regimens should be used.