Taboo populations, foods, and restrictions of Sunitinib in NATCO, India
The contraindications of Sunitinib involve specific populations, dietary restrictions, and medication conditions, and must be strictly followed to reduce treatment risks. The following provides a detailed explanation from three aspects: taboo groups, food interactions, and special restrictions.
1. Taboo population
(1) Pregnant women: May cause fetal malformation, confirm pregnancy status before medication, and take contraceptive measures during treatment and 4 weeks after discontinuation of medication.
(2) Severe liver dysfunction: Child Pugh Class C patients are contraindicated, and mild to moderate damage requires reduced monitoring.
(3) History of QT interval prolongation: Patients with uncorrected hypokalemia/magnesemia are contraindicated and require regular electrocardiogram monitoring.
2. Forbidden foods
(1) Grapefruit/grapefruit juice: inhibits CYP3A4 metabolic enzymes, may increase blood drug concentration, leading to toxicity risk.
(2) High fat diet: It is recommended to take on an empty stomach or after a low-fat meal. Fat intake>50g can reduce bioavailability by 30%.
3. Restrictive conditions
(1) Before and after surgery: Medication should be discontinued 2 weeks before major surgery and resumed after wound healing.
(2) Combination therapy: Strong CYP3A4 inhibitors (such as clarithromycin) need to be reduced by 50%, while inducers (such as rifampicin) need to be increased.
(3) Cardiovascular disease: Use with caution in patients with recent myocardial infarction or heart failure, and monitor left ventricular ejection fraction.
Disclaimer：《Taboo populations, foods, and restrictions of Sunitinib in NATCO, India》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！