The side effects and mitigation methods of Ambrisentan in Laos
Ambrisentan is an endothelin receptor antagonist primarily used for the treatment of pulmonary arterial hypertension. Its common side effects include peripheral edema, abnormal liver function, etc., most of which can be alleviated through monitoring and preventive measures. The following provides a detailed explanation from two aspects: classification of side effects and corresponding measures.
1. Common side effects and mitigation methods
(1) Peripheral edema: manifested as swelling in the limbs, which can be relieved by limiting sodium intake and elevating the lower limbs. In severe cases, diuretic treatment is required.
(2) Abnormal liver function: Elevated transaminase levels may occur, and regular monitoring of liver function is necessary to avoid concomitant use of hepatotoxic drugs.
(3) Headache: Mostly mild to moderate, medication can be adjusted until evening, and over-the-counter pain relievers can be used if necessary to relieve symptoms.
2. Serious side effects and coping strategies
(1) Liver injury: If symptoms such as jaundice and abdominal pain occur, medication should be stopped immediately and medical attention sought. During the treatment period, liver function should be monitored monthly.
(2) Decreased hemoglobin: Regular blood routine checks may be necessary, and patients with severe anemia may need to reduce or suspend medication.
(3) Reduced sperm count: Male patients should be aware of this risk and seek fertility preservation counseling if necessary.
3. Special precautions
(1) Pregnancy contraindications: It is teratogenic, and a negative pregnancy test should be confirmed before medication. Strict contraception should be used during treatment.
(2) Drug interactions: Avoid co administration with cyclosporine and potent CYP3A4 inhibitors as it may increase the risk of adverse reactions.
(3) Monitoring requirements: During the initial stage of treatment, liver function should be monitored weekly. After stabilization, it should be changed to monthly monitoring, and the efficacy should be evaluated regularly.
Disclaimer：《The side effects and mitigation methods of Ambrisentan in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！