Taboo populations, foods, and restrictions of Apalutamide in the Lao bear version
Apalutamide is an androgen receptor inhibitor used to treat prostate cancer, and its use is subject to specific contraindications, food restrictions, and medication conditions. The following provides detailed explanations from three aspects: the classification of taboo populations, taboo foods, and special restrictions, which must be strictly followed to ensure medication safety.
1. Taboo population
(1) Pregnant women: Apatamide may cause fetal malformation or miscarriage. Women of childbearing age should take effective contraceptive measures during medication and within 3 months after discontinuation.
(2) Patients with severe liver dysfunction: Child Pugh C grade patients are contraindicated, while those with moderate liver dysfunction should adjust the dosage carefully and closely monitor.
(3) Individuals allergic to active ingredients should immediately discontinue medication and seek medical attention when experiencing allergic reactions such as urticaria and difficulty breathing.
2. Forbidden foods
(1) Grapefruits and their products: Contains CYP3A4 inhibitors, which may increase the blood concentration and toxicity risk of apatamide.
(2) High fat diet: It is recommended to take it on an empty stomach or with a low-fat meal. Consuming more than 30% fat may significantly reduce drug absorption rate.
(3) Alcohol: It may increase the burden on liver function, especially when used in combination with drugs, and intake should be strictly restricted.
3. Restrictive conditions
(1) Patients with a history of epilepsy: The benefit risk ratio needs to be evaluated, and combination therapy with antiepileptic drugs may be necessary to prevent seizures during treatment.
(2) Cardiovascular disease patients: Regularly monitor blood pressure and electrocardiogram, and consider reducing dosage for newly diagnosed QT interval prolongation.
(3) Combination therapy restriction: Avoid co administration with potent CYP2C8 inducers or P-gp inhibitors as it may affect efficacy or safety.
Disclaimer：《Taboo populations, foods, and restrictions of Apalutamide in the Lao bear version》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！