The side effects and mitigation methods of Lenalidomide
The side effects of Lenalidomide involve multiple aspects such as the blood system and digestive system, and targeted relief measures need to be taken. The following is an explanation of common side effects classification and corresponding treatment methods, combined with clinical medication guidelines and suggestions for adverse reaction management.
1. Hematological system side effects
(1) Neutropenia
The incidence rate is about 30% -40%, and weekly monitoring of blood routine is required. If ANC<1.0 × 10 ⁹/L, administration should be suspended and G-CSF treatment should be used if necessary.
(2) Thrombocytopenia
It is recommended to discontinue medication when PLT<50 × 10 ⁹/L to avoid traumatic procedures. When severe bleeding occurs, platelet transfusion may be considered.
2. Digestive system side effects
(1) Nausea and vomiting
The incidence rate is about 20%, and it is recommended to take it in divided doses and with food. Prophylactic use of 5-HT3 receptor antagonists.
(2) Diarrhea
Mild diarrhea can be treated with oral montmorillonite powder, while severe diarrhea requires fluid replacement and medication suspension. Avoid high fiber diets that irritate the intestines.
3. Neurological side effects
(1) Peripheral neuropathy
Manifested as numbness in hands and feet, requiring supplementation of vitamin B family. Gabapentin can be used when the pain is obvious.
(2) Dizziness and drowsiness
Avoid driving or operating machinery. It is recommended to take medication before bedtime to reduce daytime drowsiness.
4. Other important side effects
(1) Deep vein thrombosis
High risk patients require prophylactic anticoagulation and seek medical attention immediately if swelling or pain occurs.
(2) Abnormal liver function
Regularly monitor transaminase levels, and stop taking medication and receive liver protection treatment when ALT is greater than 3 times the upper limit.
5. Special precautions
(1) Allergic reactions
The severity of rash should be evaluated, and if accompanied by difficulty breathing, medication should be stopped immediately and anti allergic treatment should be administered.
(2) Secondary malignant tumor
Long term use requires regular screening, especially for high-risk patients with hematological tumors.
Disclaimer：《The side effects and mitigation methods of Lenalidomide》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！