Taboo populations, foods, and restrictions of Pomalidomide in Laos
The contraindications of Pomalidomide involve specific populations, dietary restrictions, and medication conditions, and must be strictly followed to avoid serious risks. The following provides a detailed explanation from three aspects: classification of taboo populations, list of taboo foods, and special restriction conditions, organized according to drug instructions and clinical guidelines.
1. Taboo population
(1) Pregnant women
It has an X-level teratogenic risk and is absolutely prohibited from use. Two negative pregnancy tests are required before medication, and dual contraception is necessary during treatment until 4 weeks after discontinuation.
(2) Severe liver dysfunction
Child Pugh Class C patients are contraindicated as metabolic disorders may lead to drug accumulation. Moderate damages require a 50% reduction in usage.
(3) Uncontrolled infected patients
Immunosuppressive infections such as active tuberculosis and HIV viral load>50 copies/mL are contraindicated as they may worsen the condition.
2. Forbidden foods
(1) Grapefruit and its products
Containing strong CYP3A4 inhibitors can increase the blood concentration of pomalidomide by more than 2 times, increasing the risk of toxicity.
(2) High-fat diet
Taking it with a high-fat meal can delay the peak time by 1.5 hours. It is recommended to take it on an empty stomach or 2 hours after a meal to ensure absorption stability.
(3) Alcoholic beverages
May exacerbate liver toxicity and central inhibitory effects, alcohol consumption should be avoided during treatment.
3. Restrictive conditions
(1) Reproductive restrictions
Male patients should use condoms to prevent exposure to semen drugs, even if they have undergone vasectomy.
(2) Blood monitoring
Before treatment, ANC ≥ 1.0 × 10 ⁹/L and PLT ≥ 75 × 10 ⁹/L are required, otherwise treatment cannot be initiated.
(3) Combination therapy
Prohibiting simultaneous use with lenalidomide increases the incidence of grade 4 neutropenia to 38%.
Disclaimer：《Taboo populations, foods, and restrictions of Pomalidomide in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！