Side effects and mitigation methods of Repotrectinib in Laos
Repotrectinib, as a targeted therapy drug, has a spectrum of side effects involving multiple systems and requires a graded management strategy based on severity. The following provides a detailed explanation from three aspects: handling common side effects, dealing with severe side effects, and special protective measures to help patients safely take medication.
1. Common side effects and alleviation
(1) Neurological symptoms
The incidence of dizziness/fatigue is about 35%. It is recommended to drink water in portions and slowly change positions. People with abnormal taste can try using lemon slices or metal utensils.
(2) Digestive system response
Nausea and vomiting often occur in the early stages of medication. It is recommended to take medication after meals and have small and frequent meals. Constipation patients need to increase their dietary fiber intake to 25-30g/day.
2. Dealing with serious side effects
(1) Interstitial lung disease
New onset of dry cough/dyspnea requires immediate discontinuation of medication and chest CT examination. After diagnosis, permanently discontinue medication and, if necessary, administer corticosteroid treatment.
(2) Hepatotoxicity
Suspend medication when jaundice or transaminase levels exceed 3 times the upper limit, and reduce usage after recovery. Liver function should be monitored every 2 weeks during the first month of treatment.
3. Special protective measures
(1) Fall prevention
Due to the possibility of causing ataxia, it is recommended to install anti slip mats in the bathroom to avoid going out alone. Patients with walking difficulties need to use walking aids.
(2) Infection prevention and control
During treatment, avoid contact with patients with infectious diseases and receive inactivated vaccines. If fever>38 ℃ occurs, seek medical attention immediately and have a blood routine test.
4. Principle of dose adjustment
(1) Neurotoxicity
Symptoms at level 3 should be temporarily suspended until ≤ level 1 before reducing dosage, and medication should be permanently discontinued at level 4. Cognitive impairment patients should avoid operating dangerous machinery.
(2) Muscle injury
If CK is greater than 10 times the normal value, the medication should be stopped and the dose should be reduced after recovery. Seek medical attention immediately if experiencing muscle pain accompanied by brownish urine.
5. Key points of life management
(1) Dietary taboos
Strictly avoid grapefruit products, as they can increase blood drug concentration and increase the risk of toxicity.
(2) Sunscreen requirements
Use SPF50+sunscreen and avoid going out during the intense UV period from 10:00-16:00.
Disclaimer：《Side effects and mitigation methods of Repotrectinib in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！