Side effects and mitigation methods of Indian natco version of Ocaliva
Ocaliva, as a therapeutic drug for primary biliary cholangitis, mainly has side effects on the liver and gallbladder system, metabolic abnormalities, and skin reactions. The following provides a detailed explanation from three dimensions: common side effect management, serious adverse reaction warning, and special population precautions, with a focus on liver function monitoring and pregnancy contraindications.
1. Common self relieving side effects
(1) Skin itching: The incidence rate is about 50%, which can be relieved by cold compress and the use of non spice moisturizers. In severe cases, oral antihistamines may be considered.
(2) Fatigue: It is recommended to start the medication in small doses and gradually adapt to it with a regular schedule.
(3) Abdominal discomfort: Taking it with food can alleviate symptoms and avoid high-fat diet stimulating bile secretion.
2. Serious side effects requiring medical intervention
(1) Deterioration of liver function: When ALT/AST increases by more than 5 times ULN, medication should be stopped immediately, and liver function should be monitored every 2 weeks until recovery.
(2) Severe itching: When skin damage occurs or sleep is affected, the dosage should be adjusted or bile acid binding resin should be used in combination.
(3) HDL-C reduction: Regular blood lipid testing is necessary during treatment, and intervention should be considered when the decrease exceeds 40%.
3. Special risk prevention measures
(1) Pregnancy contraindications: It has embryotoxicity. Women of childbearing age need to confirm a negative pregnancy test before taking medication and use dual contraception during treatment.
(2) Biliary obstruction: Patients with complete biliary obstruction should not use it, while those with partial obstruction should first relieve the obstruction before evaluation.
(3) Drug interactions: When used in combination with CYP1A2 substrates (such as theophylline), blood drug concentration should be monitored to avoid toxicity accumulation.
4. Key points of patient self-management
(1) Medication time: Take it 30 minutes before breakfast every day to avoid co administration with other medications that may affect absorption.
(2) Symptom Diary: Record the degree of itching, stool consistency, and changes in fatigue, and provide quantitative data during follow-up visits.
(3) Emergency medical indication: Immediate medical attention is required for jaundice, clay colored stool, or persistent upper right abdominal pain.
Disclaimer：《Side effects and mitigation methods of Indian natco version of Ocaliva》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！