Taboo populations, foods, and restrictions of Ocaliva
The contraindications of Ocaliva involve specific disease states, physiological stages, and dietary restrictions, and must be strictly followed to avoid serious adverse reactions. The following provides a detailed explanation from three aspects: classification of taboo populations, dietary taboos, and medication restrictions, with a focus on absolute contraindications for biliary obstruction and pregnancy.
1. Absolute taboo group
(1) Patients with complete biliary obstruction: Medication may exacerbate bile stasis, leading to a rapid deterioration of liver function.
(2) Child Pugh grade C cirrhosis: contraindicated during decompensated liver function, may induce liver failure.
(3) Pregnant women: have clear embryonic toxicity, and animal experiments have shown a risk of fetal structural abnormalities.
2. Relatively taboo population
(1) Partial biliary obstruction: It is necessary to first relieve the obstruction and undergo liver and gallbladder specialist evaluation before cautious use.
(2) Moderate to severe renal insufficiency: medication frequency needs to be adjusted, and should be avoided for patients with creatinine clearance rate<30mL/min.
(3) Breastfeeding women: Medications may be secreted through breast milk, and it is recommended to suspend breastfeeding during treatment.
3. Dietary taboos
(1) High fat foods: may stimulate excessive secretion of bile and worsen abdominal discomfort symptoms.
(2) Grapefruits/citrus fruits: may inhibit CYP3A4 metabolic enzymes and increase drug exposure.
(3) Alcohol: increases the metabolic burden on the liver and has a synergistic effect with the risk of drug-induced liver injury.
4. Medication restrictions
(1) Medication timing: It should be taken on an empty stomach, at least 30 minutes before meals to ensure optimal absorption.
(2) Dose adjustment: Child Pugh B patients need to reduce dosage by 50% and monitor liver function weekly.
(3) Combination therapy restriction: Avoid taking with bile acid binding resins such as colexamide, with a minimum interval of 4 hours.
Disclaimer：《Taboo populations, foods, and restrictions of Ocaliva》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！