The side effects and mitigation methods of the Laotian version of Brigatinib in Lucius
Brigatinib, as an ALK inhibitor, commonly has side effects involving respiratory system, visual abnormalities, and gastrointestinal reactions. In severe cases, interstitial lung disease or bradycardia may occur. The following describes typical side effects and corresponding relief measures based on their frequency of occurrence, with a focus on reminding critical symptoms that require immediate medical attention.
1. High incidence of side effects (>30%)
(1) Nausea and vomiting: Taking medication after meals can alleviate symptoms, and antiemetic agents such as ondansetron can be used as needed. If it lasts for more than 72 hours, it is necessary to report to the doctor to adjust the dosage.
(2) Visual impairment: About 50% of patients experience flash vision or blurred vision, and it is recommended to avoid driving at night. Symptoms persist and require ophthalmic evaluation for retinal toxicity.
(3) Elevated creatine kinase: manifested as muscle soreness, it is recommended to avoid vigorous exercise during treatment and monitor CK levels.
2. Moderate side effects (10-30%)
(1) Interstitial lung disease: Early symptoms include dry cough and post activity shortness of breath, which require immediate discontinuation of medication and hormone therapy upon detection.
(2) Hypertension: Before treatment, control baseline blood pressure to<140/90mmHg. If headache or blurred vision occurs, emergency blood pressure reduction treatment is required.
(3) Hyperglycemia: fasting blood glucose is monitored. diabetes patients need to adjust the hypoglycemic program and be alert to ketoacidosis symptoms.
3. Serious side effects that require urgent handling
(1) Bradycardia: Discontinue medication when heart rate is less than 50 beats per minute and accompanied by dizziness. If necessary, use atropine or install a pacemaker.
(2) Acute pancreatitis: Sudden upper abdominal pain radiating to the back, requiring immediate testing for amylase and lipase.
(3) Severe infection: When patients with neutropenia experience fever>38.3 ℃, emergency blood culture and broad-spectrum antibiotic treatment are required.
4. Special protective measures
(1) Photogenic response: Use SPF50+sunscreen during treatment to avoid direct sunlight and prevent the risk of skin cancer.
(2) Bleeding tendency: Patients with thrombocytopenia should use soft bristled toothbrushes and avoid contact sports and trauma.
(3) Drug interactions: Combination use of strong CYP3A inducers (such as carbamazepine) is prohibited and should be separated by at least 14 days.
Disclaimer：《The side effects and mitigation methods of the Laotian version of Brigatinib in Lucius》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！