Medical Information

The contraindications of Belumosudil mainly involve specific physiological states and drug allergic reactions. For special populations, the dosage should be adjusted or prohibited according to liver and kidney function, age, and reproductive status. The following provides a detailed explanation from two aspects: contraindications and medication for special populations, covering key limitations and precautions for clinical use.

1. Contraindications

(1) It is contraindicated for individuals who are allergic to Besudil or any ingredients in the formulation, as severe hypersensitivity reactions such as angioedema or anaphylactic shock may occur.

(2) Pregnant women are strictly prohibited from using it, as animal studies have shown it to be embryotoxic and may lead to abnormal fetal development or pregnancy loss.

(3) Patients with severe liver function impairment (Child Pugh C grade) are contraindicated as significant inhibition of drug metabolism may lead to toxic accumulation.

2. Medication for special populations

(1) Pregnancy and lactation period

Women of childbearing age need to confirm a negative pregnancy before treatment, and effective contraceptive measures should be taken during the treatment period and one week after discontinuation of medication; Breastfeeding should be suspended during the lactation period, as it is unclear whether medication has been administered but the potential risks are uncontrollable.

(2) Child patients

The safety of medication for children aged 12 and above is equivalent to that of adults, but the dosage needs to be adjusted according to body weight; Children under 12 years old lack data and are not recommended for use.

(3) Elderly patients

Patients over 65 years old do not need to adjust their dosage, but due to decreased physiological function, there may be an increased risk of infection, and adverse reaction monitoring needs to be strengthened.

(4) Liver dysfunction

Mild damage (Child Pugh A grade) does not require adjustment; Moderate damage (Child Pugh B grade) requires a 50% reduction; Severe damage is prohibited to avoid drug accumulation and toxicity.

(5) Renal insufficiency

Mild to moderate renal dysfunction does not require dose adjustment; Severe damage or lack of data in dialysis patients, it is recommended to use with caution and closely monitor for adverse reactions.