Medical Information

The side effects of Belumosudil involve multiple systemic reactions and require targeted relief measures based on the type of symptoms. The following is an explanation from three aspects: common side effects, serious side effects, and corresponding relief methods, covering treatment recommendations for system abnormalities such as blood, digestion, and skin.

1. Common side effects and alleviation

(1) Gastrointestinal reactions: such as nausea and diarrhea, it is recommended to eat in small portions and avoid spicy foods. If necessary, use antiemetic or antidiarrheal medication.

(2) Fatigue: Adjust activity intensity, ensure sufficient sleep, and avoid activities that require high concentration such as driving or operating machinery.

(3) Headache: Maintain water intake and consider over-the-counter painkillers. If it continues to worsen, seek medical attention.

2. Hematological system side effects

(1) Thrombocytopenia: manifested as abnormal bleeding or bruising, avoid vigorous exercise and use of sharp tools, and use a soft bristled toothbrush to reduce the risk of gum bleeding.

(2) Leukopenia: Increased risk of infection. Hand hygiene should be strengthened to avoid contact with the source of infection. If fever occurs, seek medical attention promptly.

3. Skin related side effects

(1) Rash or itching: Use mild, fragrance free skincare products, avoid scratching, and in severe cases, use local or oral antihistamines.

(2) Photogenic response: Strictly protect against sun exposure, use SPF30+sunscreen, avoid direct sunlight and exposure to ultraviolet devices.

4. Serious side effects and coping strategies

(1) Hepatotoxicity: If jaundice, abdominal pain, or darkened urine color occurs, the medication should be stopped immediately and medical attention should be sought. Liver function indicators should be monitored regularly.

(2) Pulmonary toxicity: If there is a new onset of cough or difficulty breathing, immediate evaluation is required, and treatment may need to be suspended and corticosteroid therapy may be received.

(3) Hypertension: Regularly monitor blood pressure, combine antihypertensive medication if necessary, and limit sodium intake.

5. Special precautions

(1) Regular monitoring: During the treatment period, laboratory tests such as blood routine and liver and kidney function should be completed to detect abnormalities early.

(2) Drug interactions: Avoid using potent CYP3A4 inhibitors or inducers in combination, and adjust the dosage if necessary.

(3) Maternity protection: Those who have a need for childbirth should take effective contraceptive measures and avoid pregnancy during treatment and for a specific period of time after discontinuation of medication.