Side effects and mitigation methods of Palbociclib in Laos
Palbociclib, as a CDK4/6 inhibitor, commonly has side effects including hematological toxicity, gastrointestinal reactions, and fatigue, which need to be alleviated through regular monitoring, symptomatic treatment, and lifestyle adjustments. Below is an explanation of the main side effects classification and corresponding mitigation measures.
1. Hematological system side effects
(1) Neutropenia: The incidence rate is as high as 80%, and blood routine should be monitored every 2 weeks. When there is a decrease in grades 3-4, medication should be discontinued and granulocyte colony-stimulating factor (G-CSF) should be used if necessary.
(2) Anemia: The incidence rate is about 25%. It is recommended to supplement iron and vitamin B12. In severe cases, blood transfusion support is needed.
(3) Thrombocytopenia: incidence rate of 18%. Avoid vigorous exercise and sharp tool use, and use a soft bristled toothbrush to reduce the risk of gum bleeding.
2. Digestive system side effects
(1) Nausea and vomiting: incidence rate of 35%, medication can be taken after meals, and small amounts of food can be consumed in small portions. Grade 2 or above requires the use of 5-HT3 receptor antagonists.
(2) Diarrhea: incidence rate of 26%, maintain electrolyte balance, and use loperamide if necessary. Continuous diarrhea requires evaluation of the possibility of infection.
(3) Appetite loss: incidence rate of 24%, it is recommended to supplement with high protein nutrition and eat small meals frequently.
3. Systemic side effects
(1) Fatigue: The incidence rate is 41%. Reasonably arranging daily routine and moderate exercise can improve symptoms. Thyroid function needs to be evaluated in severe cases.
(2) Hair loss: incidence rate of 18%, use mild shampoo products and avoid high-temperature perm. Most of them are temporary and can be restored after discontinuation of medication.
(3) Oral inflammation: incidence rate of 15%, use mouthwash containing lidocaine and avoid spicy and irritating foods.
4. Special precautions
(1) Infection prevention: Avoid contact with sources of infection during periods of neutropenia, and seek medical attention immediately if fever occurs.
(2) Liver function monitoring: The incidence of ALT/AST elevation is about 10%, and liver function should be tested before treatment and every 2 months.
(3) QT interval prolongation: Regular electrocardiogram monitoring to avoid the use of other drugs that can cause QT prolongation.
Disclaimer：《Side effects and mitigation methods of Palbociclib in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！