What are the contraindications for Tofacitinib and can it be taken for a long time? What are the restrictions?
Tofacitinib is a JAK inhibitor primarily used to treat autoimmune diseases such as rheumatoid arthritis. Its contraindications include severe infections, active tuberculosis, etc. Long term use requires strict monitoring of the risk of infection, thrombosis, and malignant tumors, and medication for special populations needs to be carefully adjusted.
1. Contraindications
(1) Severe infection: Patients with active tuberculosis, sepsis, or other severe infections are prohibited from using it.
(2) Liver dysfunction: It is contraindicated for patients with severe liver dysfunction.
(3) Pregnancy period: Animal studies have shown embryotoxicity, and pregnant women should avoid using it.
(4) Allergic reactions: Do not use if allergic to tofacitinib or its components.
2. Long term usage restrictions
(1) Infection risk: Long term use may increase the risk of bacterial, viral, and fungal infections, and regular monitoring is necessary.
(2) Thrombosis risk: Long term high-dose use may increase the risk of deep vein thrombosis and pulmonary embolism.
(3) Malignant tumors: Long term use may increase the risk of lymphoma and other malignant tumors.
(4) Laboratory monitoring: Regular checks of blood routine, liver function, and blood lipid levels are required.
3. Special restrictions
(1) Elderly patients: Patients over 65 years old have a higher risk of infection and thrombosis, and should be used with caution.
(2) Liver dysfunction: Patients with moderate liver dysfunction need to reduce their dosage by 50%.
(3) Renal insufficiency: Patients with moderate or severe renal impairment need to adjust the dosage.
(4) Vaccination: Avoid using live vaccines.
Disclaimer：《What are the contraindications for Tofacitinib and can it be taken for a long time? What are the restrictions?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！