Usage and dosage of Astomin tablets and medication for special populations
The usage and dosage of Astomin tablets should be adjusted according to the indications, and special populations should pay attention to differences in pregnancy, liver and kidney function when using them. The following explains the standard dosing regimen, dosage adjustment principles, and precautions for special populations.
1. Usage and dosage
(1) Adult standard dosage: Oral administration 2-3 times a day, 50-100mg each time, the specific dosage needs to be adjusted according to the severity of the condition.
(2) Maintenance therapy: After symptom control, the dosage can be gradually reduced to the lowest effective dose, usually 1-2 times a day, 25-50mg each time.
(3) Maximum dose: not exceeding 300mg per day, taken in divided doses to avoid adverse reactions caused by single high-dose use.
2. Medication for special populations
(1) Pregnancy period: Animal studies have shown that it may have an impact on embryonic development. Pregnant women should weigh the pros and cons before using it with caution, and close monitoring is required during treatment.
(2) Breastfeeding period: Medications may be secreted through breast milk. It is recommended to suspend breastfeeding during treatment or adjust feeding intervals based on the half-life of the medication.
(3) Children: The safety of children under 12 years old has not been established, and the dosage should be adjusted according to their weight under the guidance of a physician, usually calculated at 1-2mg/kg.
(4) Elderly people: those with decreased liver and kidney function need to reduce their dosage by 30% -50%, starting from 25mg and slowly titrating to the effective dose.
(5) Liver dysfunction: Half the dose for Child Pugh B patients, avoid use for C patients, and monitor liver function indicators monthly.
(6) Renal insufficiency: When eGFR30-60ml/min, the dose is reduced by 25%. When eGFR30-60ml/min is less than 30ml/min, it is prohibited and creatinine clearance rate needs to be monitored.
3. Medication precautions
(1) Taking after meals can reduce gastrointestinal irritation, and the whole tablet should not be chewed.
(2) Regular monitoring of blood routine and liver and kidney function during treatment, and timely adjustment of dosage in case of abnormalities.
(3) Avoid taking it with alcohol as it may enhance central inhibitory effects.
Disclaimer：《Usage and dosage of Astomin tablets and medication for special populations》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！