What are the effects and therapeutic scope of Tofacitinib, the Laotian version of Lusius, and its efficacy
Tofacitinib is an oral JAK inhibitor mainly used to treat autoimmune diseases such as rheumatoid arthritis and psoriatic arthritis, exerting immunomodulatory effects by inhibiting inflammatory signaling pathways.
1. Function and efficacy
(1) Mechanism of action: Selective inhibition of JAK1 and JAK3 kinases, blocking the signaling of inflammatory factors such as IL-2, IL-4, IL-7, etc.
(2) Anti inflammatory effect: reduces T cell and B cell activation and production of pro-inflammatory cytokines, improves joint inflammation and injury.
(3) Immune regulation: By regulating the JAK-STAT pathway, it reduces the attack of autoimmune reactions on tissues.
2. Scope of treatment
(1) Rheumatoid arthritis: suitable for moderate to severe active adult patients with insufficient response to methotrexate.
(2) Psoriatic arthritis: Used for adult patients with active arthritis, DMARDs can be used alone or in combination.
(3) Ulcerative colitis: Treatment for moderate to severe active adult patients who are unresponsive to traditional therapies.
(4) Ankylosing spondylitis: Approved in some countries for patients with poor response to NSAIDs.
3. Other indications
(1) Alopecia areata: FDA breakthrough therapy designation for the treatment of severe alopecia areata.
(2) Juvenile idiopathic arthritis: Some pediatric patients may consider using it.
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