Medical Information

The use of Asciminib should pay attention to the management of missed doses, monitoring of adverse reactions, and dietary taboos. The precautions include multiple systemic risks such as bone marrow suppression and cardiovascular toxicity, while avoiding high-fat diets that may affect drug absorption. The following provides a detailed explanation from two aspects: medication standards and prohibited foods.

1. Medication precautions

(1) Omission treatment: If the missed dose exceeds 12 hours in the daily plan, the dose should be skipped; If the missed dose exceeds 6 hours twice a day, it will be skipped and the next dose will be taken according to the original plan.

(2) Bone marrow suppression: may cause thrombocytopenia, etc., and regular testing of whole blood cell count is necessary. If bleeding or infection symptoms occur, the dosage should be adjusted.

(3) Pancreatic toxicity: Lipase/amylase should be monitored monthly. If there is abdominal pain accompanied by elevated enzymes, medication should be suspended to investigate pancreatitis.

(4) Hypertension: Grade 3 or above should be reduced or discontinued according to the situation, and blood pressure monitoring is required during treatment.

(5) Hypersensitivity reaction: Medication should be suspended when there is a grade 3 reaction such as rash or bronchospasm.

(6) Cardiovascular toxicity: Those with risk factors need to be closely monitored, and medication intervention should be discontinued for grade 3 toxicity.

2. Taboo foods and dietary influences

(1) High fat meals can reduce drug Cmax and AUC by 68% and 62%, respectively, while low-fat meals can reduce them by 35% and 30%, respectively. It is recommended to avoid high-fat diets.

(2) Grapefruits and their products should be avoided during medication as they may affect drug efficacy through CYP3A4 interactions.