What are the applicable populations for Baricitinib in the Lao Bear version? Restrictions?
Baricitinib is suitable for patients with specific rheumatic and immune diseases, but its safety needs to be evaluated based on age, liver and kidney function, and comorbidities. It is contraindicated during pregnancy and in severely infected individuals.
1. Identify the target population for specific indications
(1) Rheumatoid arthritis: Used for moderate to severe active adult patients with insufficient response to methotrexate, requiring combination therapy.
(2) COVID-19 inpatient: it needs to be used in combination with remdesivir, which is applicable to specific severe cases requiring oxygen inhalation.
2. Absolute taboo group
(1) Active tuberculosis/hepatitis B and other infections: immunosuppression may aggravate the infection.
(2) Severe liver and kidney dysfunction: Child Pugh grade C or eGFR<30mL/min is contraindicated.
(3) Pregnancy period: Animal studies have shown embryotoxicity and strict contraception is required until 4 weeks after discontinuation of medication.
3. Careful evaluation of the population is required
(1) Elderly people (≥ 65 years old): The risk of infection and thrombosis increases, and monitoring needs to be strengthened.
(2) Chronic lung disease patients: may increase the risk of opportunistic infections.
(3) Cardiovascular high-risk individuals: The risk of thrombosis needs to be balanced.
4. Medication restrictions for special populations
(1) Children: Safety and efficacy have not been established for those under 18 years old.
(2) Breastfeeding period: Medication may be secreted into breast milk, it is recommended to discontinue medication or breastfeeding.
(3) Vaccination recipients: Avoid using live vaccines as inactivated vaccines may weaken the response.
5. Laboratory monitoring requirements
(1) Pre treatment screening: tuberculosis screening, viral hepatitis testing, and complete blood cell count are required.
(2) Regular follow-up: Monitor liver function monthly during medication, check blood lipids and neutrophil count every three months.
Disclaimer：《What are the applicable populations for Baricitinib in the Lao Bear version? Restrictions?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！