Side effects and mitigation methods of Seladelpar in Laos
The side effects of Seladelpar mainly include abnormal liver function, gastrointestinal reactions, and neurological symptoms. Specific relief measures such as discontinuation, dosage adjustment, or symptomatic treatment should be taken according to the symptoms.
1. Serious side effects requiring immediate medical attention
(1) Liver function impairment: If jaundice, darkened urine color, or persistent weakness occur, medication should be stopped immediately and medical monitoring should be sought.
(2) Allergic reactions: accompanied by difficulty breathing, facial swelling, and other hypersensitivity reactions that require urgent treatment.
(3) Arrhythmia: Palpitations or fainting may indicate QT interval prolongation and require electrocardiogram confirmation.
2. Common self relieving side effects
(1) Gastrointestinal symptoms: Nausea and diarrhea can be relieved by taking medication in divided doses or adjusting diet.
(2) Skin reaction: Mild rash. It is recommended to use moisturizer and avoid scratching.
(3) Fatigue headache: Ensure rest and hydration, usually relieved after 1-2 weeks of adaptation.
3. Abnormal management of laboratory indicators
(1) Elevated transaminase: When the ULN exceeds 3 times, administration should be suspended until recovery.
(2) Blood sodium reduction: Moderate or above requires assessment of electrolyte balance and consideration of reduction.
(3) Decreased lymphocytes: Regularly monitor the risk of infection and take preventive measures if necessary.
4. Precautions for special populations
(1) Liver dysfunction: The initial dose for Child Pugh B/C patients is halved.
(2) Elderly patients: Strengthen fall prevention as it may worsen orthostatic hypotension.
(3) Pregnancy: Animal studies have shown embryotoxicity, and strict contraception is required during medication.
Disclaimer：《Side effects and mitigation methods of Seladelpar in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！