How many pills of Ceritinib do you take a day and what are the effects
The recommended dose of Ceritinib is once daily oral administration of 450mg, which should be taken with meals to optimize absorption. The clinical effect is significant, but the dose needs to be adjusted according to toxicity reactions. The following provides specific explanations from four aspects: standard usage, dosage adjustment, efficacy evaluation, and special precautions.
1. Standard usage and dosage
(1) Conventional dose: Adult patients should take 450mg orally once a day (usually 3 150mg capsules), which should be taken with food to improve bioavailability.
(2) Medication time: It is recommended to take it at a fixed daily meal time to avoid missed doses. If missed and less than 12 hours before the next medication, skip it and do not take it again after vomiting.
2 dose adjustment plan
(1) First level reduction: When intolerable toxicity occurs, the dose is reduced to 300mg/day (2 150mg capsules).
(2) Secondary reduction: If 300mg is still not tolerated, it can be further reduced to 150mg/day (1 150mg capsule).
(3) Discontinuation criteria: If the dose of 150mg is still intolerable, permanent discontinuation is required.
3. Evaluation of treatment efficacy
(1) Effective time: The peak blood drug level is reached 4-6 hours after oral administration, and the medication is continued until disease progression or uncontrollable toxicity occurs.
(2) Clinical data: For ALK positive non-small cell lung cancer, the efficacy of elderly patients over 65 years old is comparable to that of young people, and there is no need for initial reduction.
4 Special Medication Precautions
(1) Liver dysfunction: Severe damage requires reduction, while mild to moderate damage does not require adjustment.
(2) Fertility management: Contraception is required during the treatment period and 6 months after discontinuation of medication, and male partners should use contraception for 3 months.
(3) Drug interactions: Avoid using strong CYP3A inhibitors/inducers in combination, as it may affect blood drug concentrations.
Disclaimer：《How many pills of Ceritinib do you take a day and what are the effects》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！