What is the treatment of Vemlidy fumarate tablets? What are the side effects?
Fumarate propofol tenofovir tablets (Vemlidy) are an antiviral drug used to treat chronic hepatitis B virus (HBV) infection. They effectively improve liver function by inhibiting virus replication, with significant efficacy and good safety. However, potential side effects such as renal function monitoring should be noted.
1. Indications for treatment
(1) Suitable for the treatment of chronic hepatitis B in adults and adolescents over 12 years old (weight ≥ 35kg).
(2) For patients with compensatory liver disease, it can significantly reduce HBV DNA load and improve liver inflammation.
2 therapeutic effects
(1) Virological response: After 48 weeks of treatment, approximately 94% of patients achieved HBVDNA<29IU/mL.
(2) Serological conversion: 24% of HBeAg positive patients exhibit HBeAg serological conversion.
(3) Histological improvement: Treatment for 3 years can reverse liver fibrosis in 88% of patients.
3 mechanisms of action
(1) As a prodrug of tenofovir, it is converted into the active metabolite tenofovir diphosphate in liver cells.
(2) Terminate viral DNA strand elongation by competitively inhibiting HBV reverse transcriptase.
4 Clinical advantages
(1) Targeted liver: Compared to traditional tenofovir disoproxil, the liver concentration is 5 times higher and the systemic exposure is 90% lower.
(2) High resistance barrier: No resistance related variants have been detected in global clinical trials.
(3) Convenient administration: 25mg orally once daily, unaffected by food intake.
5 Common Side Effects
(1) Gastrointestinal reactions: The incidence of nausea, abdominal pain, and diarrhea is ≥ 5%, mostly mild.
(2) Headache: The reported rate in clinical trials is 9%, and usually does not require discontinuation of medication.
(3) Fatigue: The incidence rate is about 6%, which is related to the burden of drug metabolism.
6 serious adverse reactions
(1) Renal dysfunction: may cause Fanconi syndrome or acute kidney injury, requiring regular monitoring of creatinine.
(2) Decreased bone density: Long term use may lead to osteoporosis, and it is recommended to supplement calcium supplements.
(3) Lactic acidosis: rare but life-threatening, requiring vigilance for symptoms such as fatigue and difficulty breathing.
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