Side effects and relief methods of Entrectinib
Entrectinib, as a TRK/ROS1 inhibitor, commonly has side effects involving the nervous system, cardiovascular system, and digestive system, requiring targeted monitoring and mitigation measures. The following categories describe their side effects and management methods.
1. Neurological response
(1) Common dizziness, gait instability, or cognitive impairment. During medication, avoid driving or operating machinery. If severe symptoms occur, reduce or suspend medication.
(2) May cause emotional changes or anxiety. Family members are advised to participate in monitoring and seek psychological support if necessary.
2. Effects on the cardiovascular system
(1) Be alert to the risk of QT interval prolongation. Monitor electrocardiogram before and during medication, correct electrolyte imbalance, and avoid using other QT prolonging drugs in combination.
(2) Edema or heart failure may occur. Limit sodium intake, regularly assess heart function, and seek medical attention in case of sudden weight gain.
3. Gastrointestinal discomfort
(1) Common nausea, diarrhea, or constipation. It is recommended to have small and frequent meals, replenish water during diarrhea, and increase dietary fiber during constipation.
(2) May cause an increase in liver enzymes. During treatment, abstain from alcohol, regularly check liver function, and stop taking medication immediately if jaundice occurs.
4. Abnormal blood system
(1) May lead to anemia or leukopenia. Pay attention to infection prevention, avoid contact with patients, and regularly check blood routine.
(2) Prevent bleeding during thrombocytopenia. Use a soft bristled toothbrush to avoid vigorous exercise and external injuries.
5. Other important precautions
(1) Visual impairments such as blurred or flashing should be checked immediately. Avoid strong light stimulation and have regular eye visits.
(2) Skeletal muscle pain can be treated symptomatically. Moderate activity, consider analgesic treatment in severe cases.
(3) During the reproductive age period, it is necessary to adopt efficient contraception and avoid pregnancy during treatment and within one month after discontinuation of medication.
Disclaimer：《Side effects and relief methods of Entrectinib》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！