Medical Information

Pralsetinib is a targeted therapy drug primarily used for cancer patients with specific gene mutations. Its common side effects include interstitial lung disease, hypertension, liver toxicity, etc., which require close monitoring and timely intervention. The following will provide a detailed classification of side effects and corresponding relief methods to help patients safely take medication.

Serious side effects that require immediate medical attention

(1) Interstitial lung disease/pneumonia: characterized by coughing, difficulty breathing, and fever, medication should be temporarily suspended and immediately investigated. In severe cases, medication should be permanently discontinued.

(2) Hypertension: When symptoms such as blurred vision and dizziness occur, medical attention should be sought. Treatment should be temporarily suspended for grade 3 hypertension, and permanently discontinued for grade 4 hypertension. Blood pressure should be monitored regularly during treatment.

(3) Severe bleeding, such as coughing up blood, black stool, etc., requires permanent discontinuation of medication and emergency treatment.

(4) Hepatotoxicity: manifested as jaundice, abdominal pain, etc., medication should be suspended and dosage adjusted. Relapse patients should discontinue medication.

2 Side effects that require regular monitoring

(1) Tumor lysis syndrome: High risk patients require adequate fluid replacement, monitoring of urine output, joint pain, and other symptoms.

(2) Delayed wound healing: Medication should be suspended for at least 5 days before and after surgery, and should be avoided for 2 weeks after surgery.

(3) Fertility impact: Effective contraceptive measures should be taken during treatment, and women should still use contraception within 2 weeks after stopping medication.

3 mild side effects that can be self relieved

(1) Symptoms such as taste changes, constipation, and muscle soreness are usually mild. If they persist, consult a doctor.

(2) Bone pain, fatigue, etc. can be relieved by adjusting activity intensity, and symptomatic medication can be used if necessary.

4 Principles of Dose Adjustment

(1) Gradually reduce the dose according to the degree of adverse reactions (300mg → 200mg → 100mg), and discontinue if intolerable.

(2) When used in combination with potent CYP3A inhibitors, the dosage should be reduced, while when used in combination with inducers, the dosage should be increased.

(3) Individuals with liver and kidney dysfunction need to adjust their dosage accordingly.