Side effects and mitigation methods of Sotorasib
The side effects of Sotorasib can be divided into common reactions that can be self relieved and serious adverse reactions that require urgent treatment. During medication, it is necessary to closely monitor liver and lung function and adjust the dosage according to the level of adverse reactions. Special populations (such as pregnant women and children) should use medication with caution, while also paying attention to the impact of drug interactions on efficacy.
Common side effects that can be self relieved
Skin symptoms (blisters, itching, rash, etc.), digestive system reactions (constipation, diarrhea), discomfort in the motor system (joint pain, muscle stiffness), and mild edema may gradually alleviate with prolonged medication.
Serious side effects requiring urgent medical attention
(1) Liver toxicity manifestations
Jaundice, brown urine, clay like stool accompanied by decreased appetite or upper right abdominal pain indicate liver damage, and immediate discontinuation of medication and medical attention are required.
(2) Pulmonary complications
Newly developed respiratory distress, persistent coughing, or fever may indicate interstitial lung disease, which can be fatal and requires emergency medical intervention.
3 dose adjustment plan
(1) Conventional adjustment principle
The first reduction is to 480mg/day, and the second reduction is to 240mg/day. Grade 3-4 adverse reactions require medication to be suspended and restarted at a low dose after recovery.
(2) Specific reaction processing
Diagnosed with ILD/pneumonia requires permanent discontinuation of medication; Patients with abnormal liver enzymes and elevated bilirubin should discontinue treatment; Persistent diarrhea or vomiting requires supportive treatment combined with dose adjustment.
Attention to medication for special populations
Pregnant women with fetal risks need to terminate their pregnancy, and breastfeeding is prohibited. Elderly patients do not require dose adjustment but need to strengthen liver and kidney function monitoring, and safety has not been established for the pediatric population.
5 Drug Interaction Management
Avoid using CYP3A4 strong inducers, P-glycoprotein substrates, and acid suppressants in combination. When necessary, adjust the dosage of sensitive drugs and strengthen monitoring.
Disclaimer：《Side effects and mitigation methods of Sotorasib》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！