What is the dosage of Sotorasib? How many treatment courses are generally available?
The standard dose of Sotorasib is 960mg orally per day, which needs to be adjusted in a stepwise manner according to adverse reactions. Specific supplementation rules should be followed in case of missed or vomiting. The following provides a detailed explanation from three aspects: standard dosage, dosage adjustment, and special case handling.
1. Standard dose
The standard dose for patients with non-small cell lung cancer (NSCLC) or metastatic colorectal cancer (mCRC) is 960mg orally once daily, taken at a fixed time.
2. Dose adjustment rules
(1) The first dose is reduced to 480mg/day, and the second dose is reduced to 240mg/day, applicable after the recovery of grade 3-4 adverse reactions.
(2) Diagnosis of interstitial lung disease/pneumonia requires permanent discontinuation of medication; Hepatotoxicity accompanied by abnormal elevation of bilirubin also requires permanent discontinuation.
(3) Suspend medication when nausea, vomiting, diarrhea, or liver enzyme abnormalities reach grade 3-4, and continue treatment at the downgraded dose after recovery.
3. Special case handling
(1) Within 6 hours after missing the dose, it can be supplemented, and if it exceeds 6 hours, the dose will be skipped; After vomiting, there is no need to take additional medication. The next day, take the medication according to the original plan.
(2) Elderly people do not need to adjust the dosage, but need to strengthen liver and kidney function monitoring; Pregnant and pediatric patients are not recommended to use it.
4. Duration of treatment course
The average medication duration for patients in clinical trials is about 6-12 months, but the actual course of treatment varies greatly depending on factors such as tumor response and adverse reactions. Some patients with good responses may take medication for more than 1 year.
5. Efficacy evaluation node
It is recommended to evaluate the tumor status through imaging examinations every 6-8 weeks. If the disease stabilizes or improves, continue with the original plan; If there is progress, consider adjusting the treatment plan.
6. Dose adjustment impact
When grade 3-4 adverse reactions occur, medication should be suspended. After recovery, it may be necessary to reduce the dosage to 480mg or 240mg once daily. At this time, the course of treatment calculation needs to be re evaluated.
Disclaimer：《What is the dosage of Sotorasib? How many treatment courses are generally available?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！