How many tablets does Epclusa take per day? Can it be eaten for a long time?
Epclusa, as a treatment drug for hepatitis C virus (HCV), the duration of its course of treatment needs to be personalized according to the patient's viral genotype, severity of liver disease, and treatment response. It is usually not necessary to take it for life, but the prescribed course of treatment must be completed to ensure virus clearance.
1. Standard treatment plan
(1) Patients without cirrhosis: The recommended course of treatment is 12 weeks, with a daily fixed dose oral administration (including 400mg of sofosbuvir and 100mg of velpatasvir).
(2) Compensatory cirrhosis patients: The same 12 week standard course of treatment is applicable, but liver function monitoring needs to be strengthened.
Adjustment for Special Groups 2
(1) Failure in previous treatment: If NS5A inhibitor has failed in the past, it needs to be extended to 16 weeks and combined with ribavirin.
(2) Decompensated cirrhosis: requires 12 weeks of treatment under the guidance of a liver disease specialist, and must be combined with ribavirin.
3 Evaluation criteria for drug discontinuation
(1) After completing the prescribed course of treatment, confirmation of sustained virological response (SVR12) through HCVRNA testing is considered cure.
(2) After obtaining SVR12, there is no need to continue medication, but patients with cirrhosis still need lifelong follow-up for liver cancer risk.
4 Standard Usage and Dosage
(1) The recommended dosage for adults is once daily, one tablet per oral dose (containing 400mg sofosbuvir and 100mg vapatavir).
(2) The whole tablet should be swallowed, and should not be chewed, crushed, or opened for consumption.
5. Suggested medication time
(1) It is recommended to take it at a fixed time every day to maintain a stable blood drug concentration.
(2) It can be taken with food or on an empty stomach, and the food does not affect its absorption.
6 Special circumstances adjustment
(1) Mild or moderate liver dysfunction patients do not require dose adjustment.
(2) Patients with severe liver dysfunction should use it under the guidance of a doctor.
7 Precautions
(1) If missed, it should be taken as soon as possible, and if it is close to the next medication time, it should be skipped.
(2) Do not take other antiviral drugs containing sofosbuvir at the same time.
(3) During treatment, liver function indicators should be regularly monitored.
Disclaimer：《How many tablets does Epclusa take per day? Can it be eaten for a long time?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！