Medical Information

The recommended dosage of Anamorelin is 100mg orally on an empty stomach per day. It is necessary to strictly follow the medication time and special population adjustment requirements to achieve the best therapeutic effect and reduce the risk of adverse reactions.

1 Standard Dose Protocol

(1) Adult standard dose: 100mg orally once daily, taken on an empty stomach at least 1 hour before breakfast

(2) Duration of treatment: It is recommended to take medication continuously for 12 weeks, which can be extended to 24 weeks after clinical evaluation

(3) Medication method: Swallow the whole tablet, do not break, chew or crush the tablet

Adjustment for Special Groups 2

(1) Liver dysfunction: Reduce to 50mg/day for patients with moderate liver damage, and discontinue use for patients with severe liver damage

(2) Renal insufficiency: mild to moderate without adjustment, severe (eGFR<30) reduced to 50mg/day

(3) Elderly patients: No need for adjustment, but need to strengthen adverse reaction monitoring

3 Principles of Dose Adjustment

(1) Omission treatment: skip the daily dose for more than 12 hours and prohibit double supplementation

(2) Adverse reaction management: Discontinue medication in case of grade 2 toxicity, reduce dosage to 50mg/day after recovery

(3) Discontinuation criteria: Prolonged Level 3 toxicity or permanent discontinuation of any Level 4 toxicity

4 Precautions for combination therapy

(1) CYP3A4 inhibitor: When used in combination, reduce dosage by 50% and monitor QT interval

(2) Drugs for diabetes: it may be necessary to adjust the hypoglycemic program and monitor the changes of blood sugar

(3) Anticoagulants: Increase INR monitoring frequency to prevent bleeding risk