What is Encorafenib? Detailed Introduction
Encorafenib is an oral small molecule BRAF kinase inhibitor developed by Array Corporation in the United States and approved for market by the FDA in 2018. Mainly used for the treatment of melanoma, colorectal cancer, and non-small cell lung cancer carrying BRAF V600E/K mutations, it is often used in combination with bimetinib or cetuximab, and has the characteristics of targeted and precise treatment.
1. Basic information of the drug
(1) Common names: Konafenib, Enkafenib
(2) Product Name: Braftovi
(3) Dosage form: 75mg hard gelatin capsule, beige cap print "A", white body print "LGX75mg".
2 Indications and Targets
(1) Melanoma: Combination therapy with bimetinib for BRAF V600E/K mutation unresectable or metastatic melanoma
(2) Colorectal cancer: Combination therapy with cetuximab for BRAF V600E mutant metastatic colorectal cancer
(3) Non small cell lung cancer: combined treatment with bimetinib for BRAF V600E mutant metastatic NSCLC.
(4) Target: Specific inhibition of BRAF V600E/K gene mutations.
3. Usage and dosage adjustment
(1) Standard dose: 450mg orally per day, dosage adjustment is required for combination therapy
(2) Adverse reaction reduction: gradually reduce to 300mg/225mg/150mg according to toxicity grading
(3) Liver and kidney function: Mild to moderate damage does not require adjustment, severe lack of data.
4. Medication for special populations
(1) Pregnancy and lactation: may cause fetal harm, prohibited during lactation
(2) Pediatric medication: Safety not established
(3) Elderly medication: No special adjustments required.
5 Market Status
(1) Domestic listing: not yet approved in China
(2) Generic drugs: Currently, there are no generic drugs on the market.
Disclaimer：《What is Encorafenib? Detailed Introduction》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！