How effective is Upadacitinib
Upadacitinib, as a selective JAK1 inhibitor, has shown significant efficacy in various immune diseases. Its therapeutic effect can be evaluated from multiple dimensions such as clinical symptom improvement rate, imaging progression inhibition, and biomarker changes. The specific efficacy varies depending on the indication type and individual differences.
Therapeutic effect of rheumatoid arthritis
(1) ACR50 response rate: 52% after 24 weeks of treatment, significantly better than adalimumab (36%) and methotrexate (28%), with an average reduction of 78% in joint swelling in moderate to severe patients.
(2) Imaging progress: Continuous medication for 1 year can inhibit 76% of joint bone erosion progression, and the Sharp score change is 1.8 points lower than the placebo group.
Therapeutic effect of atopic dermatitis
(1) Skin lesion clearance rate: In the 15mg dose group, the EASI75 compliance rate was 71% at 16 weeks, and 60% of patients showed improvement of itching NRS score ≥ 4 points.
(2) Long term maintenance effect: After 52 weeks of continuous treatment, 85% of patients can maintain an IGA score of 0/1, and the recurrence rate is reduced by 43% compared to the intermittent medication group.
Therapeutic effect of ankylosing spondylitis
(1) ASAS40 response rate: 45% after 14 weeks of treatment, better than the placebo group (18%), with an average reduction of 39mm in VAS scores for nighttime back pain.
(2) Functional improvement: Among patients with a baseline BASFI score of ≥ 5, 64% achieved a daily life functional improvement of BASFI<3 at 24 weeks.
4. Efficacy of Psoriatic Arthritis
(1) Composite endpoint compliance rate: At 24 weeks, the synchronous compliance rate of ACR50+PASI75 in skin lesions was 38%, and the resolution rate of finger inflammation was 2.1 times higher than that of traditional DMARDs.
(2) Improvement of attachment site inflammation: Ultrasound confirmed that the resolution rate of attachment site inflammation reached 67%, and the therapeutic effect can be sustained for 52 weeks.
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