Medical Information

The side effects of Letermovir mainly include blood system abnormalities, digestive system reactions, and drug interaction risks, and its mitigation methods need to be combined with monitoring adjustments and preventive measures.

1. Serious side effects requiring medical intervention

(1) Allergic reactions, such as angioedema or anaphylactic shock, require immediate discontinuation of medication and treatment with adrenaline.

(2) Hematopoietic suppression: Neutropenia may occur, and regular monitoring of blood routine and prevention of infection are necessary.

(3) Hepatotoxicity: When the transaminase level increases by more than 5 times the ULN, the medication should be stopped and liver function recovery should be monitored.

2. Common manageable side effects

(1) Gastrointestinal reactions: Nausea and diarrhea can be relieved by taking medication in divided doses or in combination with antiemetic agents.

(2) Headache: Most cases are mild, and appropriate rest or acetaminophen can improve symptoms.

(3) Peripheral edema: Limiting sodium intake and elevating limbs can help alleviate edema.

3. Drug interaction prevention

(1) CYP3A inhibitors: Avoid using potent inhibitors (such as ketoconazole) in combination to prevent high blood drug concentrations.

(2) Immunosuppressants: When used in combination with cyclosporine, adjust the dose of letamivir to half the dose.

(3) P-gp substrates: Drugs such as digoxin need to be monitored for concentration to enhance their antiviral properties.

4. Precautions for special populations

(1) Liver damage patients: Child Pugh B/C grade need to adjust dosage and strengthen monitoring.

(2) Elderly patients are more prone to renal dysfunction and need to adjust the dosage according to creatinine clearance rate.

(3) Pregnancy period: Animals show embryotoxicity, and women of childbearing age need to take effective contraception.