How many tablets of Adagrasib can I take in a day for a long time
The standard dose of Adagrasib is 600mg twice daily (2 300mg tablets), taken at 12 hour intervals and continuously administered until disease progression or intolerable toxicity occurs. The long-term safety of its use has been validated in clinical trials, but regular monitoring of adverse reactions is necessary.
1. Conventional usage and dosage
(1) Single dose: Take 600mg orally each time (2 300mg tablets), and swallow the whole tablet.
(2) Medication frequency: Take twice a day at a fixed time, with a strict interval of 12 hours (such as 8am/8pm).
(3) Treatment requirements: Continue taking medication until the disease progresses or the doctor determines that the medication needs to be stopped, with no predetermined treatment period limit.
2. Precautions for administration
(1) Usage: Can be taken with food or on an empty stomach, but should avoid taking with grapefruit products.
(2) Omission treatment: If it is more than 6 hours before the next administration, it can be taken immediately; Skip if ≤ 6 hours and prohibit double dosage.
(3) Dose adjustment: In the event of ≥ grade 3 adverse reactions, administration should be suspended, and may need to be reduced to 400mg per dose after recovery.
3. Long term medication management
(1) Safety data: The median duration of treatment in key trials was 8.2 months, with the longest duration of medication exceeding 2 years.
(2) Monitoring requirements: Regular check of liver function (once every 3 weeks for the first 3 months), electrocardiogram (QT interval), and electrolytes are required.
(3) Discontinuation criteria: Disease progression or irreversible toxicity (such as interstitial lung disease, severe liver injury, etc.).
4. Medication for special populations
(1) Patients with liver injury: Moderate to severe liver dysfunction should reduce the dosage to 300mg/time, twice a day.
(2) Elderly patients: Those aged 65 and above do not need to adjust the dosage, but it is necessary to strengthen the monitoring of adverse reactions.
(3) Drug interactions: Avoid using strong CYP3A4 inhibitors/inducers in combination and adjust the dosage if necessary.
Disclaimer：《How many tablets of Adagrasib can I take in a day for a long time》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！