Medical Information

There are multiple restrictions on the use of Binimetinib, including contraindications for special populations, dosage adjustment requirements, and storage standards. The following provides specific explanations from four aspects: medication contraindications, restrictions on special populations, dose adjustment restrictions, and storage conditions.

1. Medication contraindications

Patients with severe liver function impairment (Child Pugh C grade) are contraindicated with pemetrexed, as significantly increased drug exposure may lead to an increased risk of toxicity.

2. Special population restrictions

(1) Pregnancy period

Based on animal studies showing embryonic toxicity, strict evaluation of the risk benefit ratio is required for use during pregnancy, and medication can only be administered after confirming the pregnancy status.

(2) Lactation period

It is unclear whether the medication has entered human milk, and breastfeeding should be stopped during the treatment period and within 3 days after the last administration.

(3) Children

The safety and efficacy of patients under 18 years old have not been established, and there is a lack of clinical data support.

(4) Elderly people

Although there is no difference in overall safety compared to young adults, it is necessary to strengthen liver function monitoring as age-related liver function decline may affect drug metabolism.

3. Dose adjustment limit

(1) Liver dysfunction

Patients with moderate or severe liver function impairment should reduce their dosage to 30mg twice a day, and mild impairment does not require adjustment.

(2) Renal insufficiency

Patients with severe renal impairment do not need to adjust the dosage, but close monitoring of adverse reactions is necessary.

4. Storage condition restrictions

It needs to be stored in its original packaging at 20 ° C-25 ° C, and is allowed to be stored in an environment of 15 ° C-30 ° C for a short period of time to avoid high temperature or freezing.

5. Regional restrictions

At present, the drug has not been approved for marketing in Chinese Mainland, so it needs to be obtained through legal and special channels. Pay attention to identifying the authenticity of the drug.